Precision Protein Engineering

Rewriting Proteins to Reverse Neurodegeneration

Tiragena combines genetic code expansion, precision protein design, and translational delivery science to build durable therapies for neurodegeneration and age-related decline. We turn frontier biology into clinically focused programs with measurable patient impact.

About Tiragena

Pioneering Protein Engineering

Our story

Our name reflects our mission—combining innovation in genetic technology with regenerative approaches to age-related disease.

Our mission

To revolutionize therapeutic development through proprietary Genetic Code Expansion (GCE) technology, advancing from precision-engineered research proteins to breakthrough antibody-drug conjugates and transformative in vivo protein editing therapies that prevent and treat age-related diseases.

Our vision

To become a leading biotechnology company that fundamentally changes how we treat aging and neurodegeneration by engineering proteins to maintain their function throughout life—preventing disease before irreversible damage occurs.

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Our values

  • Scientific Excellence — Rigorous, research-driven innovation built on 20+ years of GCE expertise
  • Patient Focus — Every decision guided by creating meaningful impact for patients and families affected by devastating diseases
  • Safety First — Developing transient, reversible therapies that prioritize patient safety
  • Collaboration — Building partnerships across academia, industry, and clinical medicine
  • Innovation with Purpose — Advancing breakthrough science to address critical unmet medical needs

Strategic Approach

Three Phases to Transform Medicine

Phase I: Building the Foundation

Premium GCE-engineered research proteins establishing revenue and scientific credibility.

Phase II: Advancing Cancer Treatment

Next-generation antibody-drug conjugates for targeted oncology.

Phase III: Transforming Neurology

Revolutionary protein editing therapies for Alzheimer's, Parkinson's, ALS, and age-related conditions.

Leadership

World-Class Scientific Leadership

Prof. Nediljko Budisa

Co-Founder & Chief Scientific Officer

  • Pioneer in Genetic Code Expansion with 20+ years of research.
  • 100+ peer-reviewed publications in synthetic biology and protein engineering.
  • International recognition as a leader in non-canonical amino acid incorporation.
  • Former positions at leading research institutions in Europe and Canada.

Prof. HamidReza KarbalaeiHeidari

Co-Founder & Chief Executive Officer

  • Expert in protein engineering and biomanufacturing.
  • Extensive experience in biotech development and commercialization.
  • Deep expertise in GCE platform development and scale-up.
  • Track record of translating academic research into commercial applications.

Scientific Advisory Board

Our advisory network combines translational neuroscience, protein engineering, clinical strategy, and regulatory expertise to guide program design, biomarker plans, and trial readiness.

Location

Why Winnipeg?

  • Access to world-class research institutions.
  • Strong government support for biotech innovation.
  • Cost-effective operations.
  • Growing life sciences ecosystem.
  • Strategic location for North American expansion.

Recognition

Milestones & Achievements

  • Federally and Provincially Registered Corporation
  • IRAP and NSERC funding eligibility.
  • SR&ED tax credit qualification.
  • Multiple patent applications filed.
  • Strategic partnerships under development.

Our Science

Genetic Code Expansion

Nature's genetic code uses 20 standard amino acids to build all proteins. Tiragena's proprietary technology expands this code, enabling us to incorporate non-canonical amino acids (ncAAs) with novel properties—creating therapeutic proteins impossible to achieve in nature.

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Publications Peer-reviewed research Science Blog Latest insights

Therapeutic Pipeline

From Research to Patients

Our portfolio spans engineered research proteins, next-generation ADCs, and in vivo protein editing programs aimed at diseases of aging and neurodegeneration.

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Collaboration

Partnerships

We collaborate with academic centers, clinical partners, and industry to accelerate translation. If you are interested in collaboration, reach out through our contact page.

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Join Our Team

Build the Future of Medicine

We are building a multidisciplinary team passionate about protein engineering, translational science, and patient impact.

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20+
Years of GCE Research

Get in Touch

Contact Us

General, investor, partnership, and media inquiries: info@tiragena.com

Scientific and technical inquiries: science@tiragena.com

Winnipeg, Manitoba

Canada

Send a message

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For scientific questions, you may prefer science@tiragena.com.