Protein-level intervention
- mRNA-based delivery with natural degradation.
- Dose-controllable and reversible.
- No DNA cutting or permanent mutations.
- Established LNP–mRNA regulatory precedent.
Our ScienceOur Science
Protein Editing and Genetic Code Expansion for TherapeuticsProtein Editing and Genetic Code Expansion for Therapeutics
Tiragena engineers proteins using genetic code expansion and orthogonal translation—incorporating non-canonical amino acids at defined sites without permanent genomic change.
Tiragena engineers proteins using genetic code expansion and orthogonal translation—incorporating non-canonical amino acids at defined sites without permanent genomic change.
Scientific Platform Overview
Every protein in the body is built from a constrained amino acid alphabet. Those building blocks have served life for billions of years, but they can be oxidized, aggregate, or fail under stress. Tiragena's orthogonal translation system introduces additional coding capacity, enabling site-specific insertion of non-canonical amino acids designed for oxidation resistance, aggregation control, photostability, and structural integrity.
PlatformPlatform
Platform at a glancePlatform at a glance
VLP delivery, translation with non-canonical amino acids, and protection mechanisms against aggregation and oxidative stress — without genome editing.
VLP delivery, translation with non-canonical amino acids, and protection mechanisms against aggregation and oxidative stress — without genome editing.
ResearchResearch
Scientific presentationScientific presentation
A research presentation on genetic code expansion and orthogonal translation — foundational to the Tiragena platform.
A research presentation on genetic code expansion and orthogonal translation — foundational to the Tiragena platform.
Protein Editing vs. Gene EditingProtein Editing vs. Gene Editing
Our protein-level engineering paradigm is designed around transient delivery and reversibility—distinct from permanent DNA modification.
Our protein-level engineering paradigm is designed around transient delivery and reversibility—distinct from permanent DNA modification.
Gene editing
- Permanent genomic modification.
- Irreversible DNA-level changes.
- Higher off-target genomic risk profile.
- Different regulatory and safety considerations.
Research ApplicationsResearch Applications
The platform is grounded in decades of research, a large publication record, and an expanding body of translational data supporting protein-level intervention for age-related and neurodegenerative disease biology.
The platform is grounded in decades of research, a large publication record, and an expanding body of translational data supporting protein-level intervention for age-related and neurodegenerative disease biology.
Explore the broader ChemSynBio laboratory research archive and related scientific outputs. ChemSynBio laboratory
PublicationsPublications
Peer-reviewed highlights from our catalog. View the complete archive with filters and expandable articles.
Peer-reviewed highlights from our catalog. View the complete archive with filters and expandable articles.
Cold Orthogonal Translation
Psychrophilic PylRS-enabled orthogonal translation advances efficient ncAA incorporation.
Engineered Whole-Cells for PET Bioremediation
Antibiotic-free whole-cell catalyst architecture for practical plastic hydrolysis workflows.
Critical Assessment of Genetic Code Expansion
Foundational analysis of current paradigms, efficiency limits, and future design directions.
Noncanonical Amino Acids Special Issue
Comprehensive synthesis of expanding amino acid chemistry in modern biotechnology.
Explore the therapeutic pipelineExplore the therapeutic pipeline
See how genetic code expansion progresses from research proteins toward neurodegenerative therapeutic programs.
See how genetic code expansion progresses from research proteins toward neurodegenerative therapeutic programs.